Hydrolytic and Peroxyhydrolytic Degradation of Nerve Agent Analogs with Low Molecular Weight Bimetallic Catalysts
Abstract
The proposed research focused on the detoxification of both G- and V-types nerve agents by chemical means. Two key objectives are (i) developing novel hetero-bimetallic Fe/Zn TACN complexes that facilitate efficient hydrolysis of both organophosphate esters and G-agents, and (ii) synthesizing Mn2-complexes of TACN and probe their activities in catalyzing oxidative degradation of VX-simulants (sulfides) using either O2 or H2O2. Early on, we succeeded in the preparation of the tethered bis-TACN ligands. However, clean synthesis of hetero-bimetallic Fe/Zn complexes remains a challenge. The effort during the later stage (2002-2004) was focused on the activation of H2O2 and tBuO2H for the oxygenation of organic sulfides, which is the key step in V-agent degradation. Proficiency of bimetallic Mn-TACN system was explored and the effect of co-catalysts was evaluated. It is also found that the mononuclear Mn-TACN system can activate tBuO2H and exhibits one of the highest TOFs (turn-over frequency) in the oxygenation of sulfides by tBuO2H. Also identified is an organic soluble polyoxometallate catalyst, (Bu4N)4GAMMA-SiW10O34(H2O)2, which displays both a remarkable 100% utility of H2O2 in catalytic sulfide oxygenation and chemical selectivity for sulfoxide formation. Several graduate and undergraduate students (both female and underrepresented groups) participated all phases of ARO funded research.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA429791
Entities
People
- Tong Ren
Organizations
- University of Miami