A System for Discovering Bioengineered Threats by Knowledge Base Driven Mining of Toxin Data

Abstract

The overall goal of this project is to establish a Toxin Knowledge Base (TKB) a bioinformatics resource primarily focused on molecular information about toxins and other virulence factors that are the natural products of biological and potential biological warfare (BW and PBW) agents. The resource will be ruined to assimilate, synthesize, analyze and disseminate genomic and structural information on BW and PBW genes and their products. The TKB will be designed and developed to serve as a powerful analysis and decision system tool for the intelligence community. In this first annual report we describe in detail the TKB system that we have developed that can be used to identify homologs of toxins. The TKB contains molecular, biological and structural information of about 1000 toxins and is still being expanded.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2004
Accession Number
ADA429799

Entities

People

  • Subramanyam Swaminathan

Organizations

  • Brookhaven National Laboratory

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Artificial Intelligence
  • Biological Products
  • Biological Toxins
  • Biological Warfare
  • Classification
  • Computational Science
  • Crystal Structure
  • Data Mining
  • Databases
  • Hidden Markov Models
  • Intelligence Community
  • Machine Learning
  • Quantum Cascade Lasers
  • Three Dimensional
  • User Interface
  • Web Browsers

Readers

  • Critical Infrastructure Protection in CBRN and WMD Threats.
  • Distributed Systems and Data Platform Development
  • Molecular Genetics

Technology Areas

  • Biotechnology