The Role of Calgranulin Overexpression in Breast Cancer Progression

Abstract

The mechanism responsible for the progression of breast cancer to estrogen independence is currently unknown. We have demonstrated a strong correlation between elevated expression of Calgranulin A and Calgranulin B and the loss of estrogen dependence. Experiments using estrogens and antiestrogens have demonstrated that this is not the result of direct interference with estrogen receptor signaling and must therefore require additional steps. Interestingly, we have also shown that expression of calgranulins in estrogen independent breast cancer cells is quite variable and may be differentially regulated during the cell cycle. We are currently in the process of determining if forced overexpression of calgranulin A and/or calgranulin B can drive cells to lose their dependence on estrogens for growth.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2004
Accession Number
ADA430038

Entities

People

  • John J. Pink

Organizations

  • Case Western Reserve University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Compounds
  • Confocal Microscopy
  • Diseases And Disorders
  • Dna Microarrays
  • Estrogens
  • Genes
  • Microarray Analysis
  • Neoplasms
  • Standards
  • Tissue Extracts

Readers

  • Breast cancer cell signaling and growth regulation.