Molecular Mechanisms of Filovirus Cellular Trafficking

Abstract

The filoviruses, Ebola and Marburg, are two of the most pathogenic viruses, causing lethal hemorrhagic fever in humans. Recent discoveries suggest that filoviruses, along with the phylogenetically or functionally related viruses, utilize a complex mechanism of replication, exploiting multiple cellular components, including lipid rafts, endocytic compartments, and vacuolar protein-sorting machinery. In this review, we summarize these recent findings and discuss the implications for vaccine and therapeutics development.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2003
Accession Number
ADA430049

Entities

People

  • Alan Schmaljohn
  • Catharine M. Bosio
  • James C. Burnett
  • M. J. Aman
  • Rekha G. Panchal

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antiviral Agents
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Disease Outbreaks
  • Diseases And Disorders
  • Ebola Virus
  • Infection
  • Microorganisms
  • Proteins
  • Proteomics
  • Rna Viruses
  • Viral Structures
  • Virion
  • Viruses

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Infectious Disease/Epidemiology
  • Molecular Genetics

Technology Areas

  • Biotechnology