Doxycycline Is Anti-Inflammatory and Inhibits Staphylococcal Exotoxin-Induced Cytokines and Chemokines

Abstract

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2003
Accession Number
ADA430153

Entities

People

  • Marilyn Buckley
  • Teresa Krakauer

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antigens
  • Biological Factors
  • Biological Toxins
  • Blood
  • Body Fluids
  • Cells
  • Chemistry
  • Chemotherapy
  • Cytokines
  • Diseases And Disorders
  • Immune System
  • Infectious Diseases
  • Lymphocytes
  • Production
  • Proteins

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Microbial Pathology