Development of General Antibiotics Against Known and Unknown Pathogens

Abstract

The initial synthetic work was started at April of 2003. The primary objectives were to synthesize hybrid sugar and aminoglycoside antibiotic with N-1 modification. The synthesis of pyranmycin with hybrid sugar has been accomplished. The synthetic approach of N-1 modification has yielded several aminoglycosides that are active against various resistant bacteria. In addition we have devoted effort for the development of kanamycin class aminoglycosides. Several compounds with low micromolar activity against resistant bacteria have been synthesized.

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Document Details

Document Type
Technical Report
Publication Date
Feb 10, 2005
Accession Number
ADA430309

Entities

People

  • Cheng-wei T. Chang

Organizations

  • Utah State University

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antiviral Agents
  • Bacteria
  • Classification
  • Clinical Trials
  • Glycosides
  • Information Operations
  • Inhibition
  • Microorganisms
  • Military Research
  • Pathogenic Bacteria
  • Pharmacologic Actions
  • Scientists
  • Security
  • Students

Fields of Study

  • Chemistry

Readers

  • Microbial Pathology
  • Molecular and Cellular Biochemistry
  • Technical Research and Report Writing.