Adenovirus and its Vector for Developing Vaccines Against Biological Warfare Agents

Abstract

This memorandum reviews a new platform for the development of vaccines against biological warfare (BW) agents. The noted platform uses adenovirus as a vector to deliver DNA that encodes for key antigens of BW agents. Once inside the mammalian cell, this adenovirus vectored vaccine induces rapid immune responses. This memorandum describes the basic virology of adenovirus, methods used to modify adenovirus as vaccination vector, advantages of adenovirus vector for developing vaccines against BW agents such as Ebola and anthrax, and the potential obstacles, with proposed solutions, for the use of adenovirus vector.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2004
Accession Number
ADA430321

Entities

People

  • Qiaohua Wu

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adenoviruses
  • Cells
  • Chemistry
  • Health Services
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Microbiology
  • Microorganisms
  • Proteins
  • Therapy
  • Vaccines
  • Virology
  • Viruses

Fields of Study

  • Biology

Readers

  • Defense Acquisition Program Management
  • Immunology
  • Infectious Disease/Epidemiology

Technology Areas

  • Biotechnology