The Effects of Diesel Exhaust and Stress on the Acute Phase Response and Symptoms in the Chemically Intolerant
Abstract
Purpose: The proposed study is designed to test a model of Gulf War Illness, in which simultaneous acute exposures to DE and psychological stress cause increased symptoms via the acute phase response (APR), among individuals reporting chemical intolerance (CI). Scope/Approach: In this double-blind, 2 (DE exposure) X 2 (high vs. low CI) X 2 (stress vs. no stress) design, 110 healthy men and women, ages 21 to 45, will be exposed, during two one-hour exposure sessions, to DE standardized to 300 microgram/cu m PM10 and to ambient air masked with a one-minute pulse of DE. Symptoms, end-tidal CO2, markers of the APR in peripheral blood and markers of inflammation in the lungs and nasal mucosa will be assessed at baseline and up to 24 hours post exposure. Results and Major Findings: The diesel exhaust exposure system has been constructed and CO, NOx, PM2.5, PM10, BC, volatile fraction, and particle distributions generated in the CEF have all been measured. Further tests are being conducted to improve the delivery method in order to attain a quick and stable target concentration of PM10. Significance: The controlled exposure system is generating consistent concentrations of DE. Subject exposures can begin when the DOD IRB has approved the study protocol for testing of human subjects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2004
- Accession Number
- ADA430323
Entities
People
- Howard Kipen
- Lunfeng Zhang
- Nancy L. Fiedler
- Paul Lioy
- Robert Laumbach