Mammaglobin and Lipophilin Related Molecules in Normal and Tumor Human Breast Tissue: Expression Hormone Regulation and Functional Analysis
Abstract
Genes, expression of which is breast specific or is altered during breast tumorigenesis, represent potential targets for new preventive and curative strategies. Such genes, Mammaglobin (MGB1), hSBEM (Human Small Breast Epithelial Mucin), Psoriasin, Estrogen receptor beta (hERB) and SRA (Steroid receptor RNA activator), have been studied during the time of this Award (July 2OO1-July 2004). We found that: MGB1 expression correlates with ER (an established breast cancer prognostic and predictive factor), but is not modified by hormone treatments, suggesting it might be a new independent breast cancer prognostic marker. hSBEM, we identified a new breast specific gene which represents an attractive candidate for a new breast tumor marker with obvious potential for cancer diagnostics and treatment SRA, previously believed to belong to the family of non-coding RNA and able to activate steroid receptor activity, is indeed translated into a protein which we suspect also interfers with estrogen signaling pathway. Psoriasin, highly expressed in high risk DCIS, can contribute to breast tumor progression through modulation of Jab1 activity and is a target gene of ER-beta. hERB isoforms have promoter-specific differential activities and modulate the response of breast cancer cells to antiestrogen treatment. this suggests that these isoforms may have a role in differentially modulating estrogen action during breast tumor progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2004
- Accession Number
- ADA430357
Entities
People
- Etienne R. Leygue
Organizations
- University of Manitoba