Bone Growth Mechanical Stimulus and IGF-I
Abstract
Available data indicate that the genetic susceptibility for low bone mass is present very early in life. The aim of this project is to establish whether bone acquisition in teenagers who have sustained a fracture and have low bone mass can be enhanced by changing : environmental factors, such as mechanical loading. The effects of a twelve-month mechanical intervention on musculoskeletal development will be studied and the results will be compared to matched teenagers undergoing no intervention. This study also examines the possible relations between the cross-sectional properties of bone and circulating levels of IGF-I, IGF-binding protein-3, and IGF-I genotypes in teenagers ages 15 to 20 years with sport-related fractures. The possible relations between bone acquisition induced by mechanical stimulus and circulating levels of IGF-I and the IGF-I genotype will be assessed. The cross-sectional arm of this project was completed with 100 females in July, 2003. From this group, 48 subjects with low measurements for bone density or bone size were asked to enroll in phase two, the longitudinal arm. An intervention group and a control group have been formed; 24 females are using the vibration intervention system for 10 minutes/day and taking calcium 500 mg daily, 24 controls are taking calcium 500 mg daily.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA430393
Entities
People
- Vicente Gilsanz
Organizations
- Children's Hospital Los Angeles