Interactions of Multiple Fluorescent Labels in Biological Sensing

Abstract

The long-term goals of this project have been to develop new strategies for the use of oligonucleotides tagged with multiple fluorescent labels as biosensing probes of specific nucleic acid sequences. First, we have designed new classes of fluorescent labels for DNA. Second, we have developed novel modes of interaction between fluorescent labels, leading to color changes on detection of nucleic acids Finally, we have developed new chemistries for joining DNA strands which can be applied to color-changing strategies. These lines of research led to useful developments in biosensing, and have opened up new areas of investigation for the future.

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Document Details

Document Type
Technical Report
Publication Date
Jul 19, 2003
Accession Number
ADA430439

Entities

People

  • Eric T. Kool

Organizations

  • Stanford University

Tags

Communities of Interest

  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Acids
  • Bacteria
  • Cell Physiological Processes
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Detection
  • Energy
  • Energy Transfer
  • Fluorescence
  • Molecules
  • Nucleic Acids
  • Nucleosides
  • Pathogenic Bacteria
  • Polymers
  • Programmed Cell Death
  • Sequences

Fields of Study

  • Chemistry

Readers

  • Molecular Genetics
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Biotechnology