The Toxin and Virulence Database: A Resource for Signature Development and Analysis of Virulence
Abstract
In this joint effort with the University of Alabama at Birmingham, Walter Reed, MITRE and USAMRIID, we are developing a comprehensive database for microbial toxins and virulence factors (www.tvfac.lanl.gov). This database will contain all known toxins and virulence factors as well as their homologs. Each TVFac record and the associated gene records will be fully annotated to include all relevant sequence and structural information as well as biological, epidemiological, and clinical information Human annotation, sequence-based data analysis, protein structure prediction, and natural language-based data mining will be integrated for a comprehensive understanding of the common mechanisms leading to pathogenesis. This effort is intended to provide necessary infrastructure for studying the common mechanisms of virulence and identifying common "themes" utilized by microorganisms to cause disease. Bioinformatic tools are being developed to allow users to explore the database and perform detailed analysis and to support detection and countermeasure development efforts. This effort is a continuation and expansion-of the USAMRIID-funded effort for a "Cooperative Relational Database Initiative For Threat Reduction.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2004
- Accession Number
- ADA430566
Entities
People
- Murray A. Wolinsky
Organizations
- Los Alamos National Laboratory