Tumor Vaccination With Cytokine-Loaded Microspheres
Abstract
A single intra-tumoral injection of IL-l2 + GM-CSF-encapsulated microspheres promoted the suppression of primary tumor growth, prevented the development of additional tumors and extended survival in the her2-neu transgenic FVB/neuN murine mammary tumor model. Induction of a long-lived, systemic, tumor-specific immune response was demonstrated in adoptive cell transfer studies, cytotoxic T-cell assays, in vivo lymphocyte subset depletion studies and analysis of serum anti-tumor antibody levels. Repeated treatment was more effective than single treatment in inducing complete tumor regression, secondary tumor suppression and enhancing survival, however long-term cures were not obtained. The failure to achieve complete cure was not due to the inability to maintain anti-tumor immunity or the infiltration of tumors by lymphocytes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA430611
Entities
People
- Nejat K Egilmez
Organizations
- University of Louisville