Molecular Biology and Prevention of Endometrial Cancer
Abstract
To increase our understanding of the molecular aberrations associated with endometrial carcinogenesis and the biologic mechanisms underlying the protective effect of oral contraceptive therapy. Methods: 1) Oligonucleotide microarray analysis was performed on a panel of endometrial cancers. 2) A subset of adenocarcinoma cases from the International DES Registry was analyzed for MSI and the poor quality of the DNA from many of these cases prohibited an adequate analysis of the entire set. The cases are currently being evaluated for PTEN expression. 3) We are in the process of analyzing the endometrium from cymologous macaques that were exposed to long term progestins as part of the three year randomized controlled trial. 4) A clinical trial comparing progestin versus placebo is underway that will facilitate investigation of the effects of progestin exposure on the endometrial lining Results: 1) Different histological types of endometrial cancer have unique genomic expression patterns. 2) Endometrioid endometrial cancers with microsatellite instability have a genomic expression pattern that is different from those microsatellite stability.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA430734
Entities
People
- George L. Maxwell
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine