Ring-Closing Metathesis of Macrocyclic Compounds and Cross-Metathesis of Allyl Esters of Amino Acids Leading to Peptidominetics
Abstract
The preparation of a dynamic combinatorial library of peptides using the cross-metathesis of allyl esters of amino acids was examined in a model study. This preliminary investigation employed Grubbs' second generation catalyst for the ring-closing metathesis of unique macrocyclic systems. An N-allyl lactam function, that was part of the large ring, was reacted with allyl esters of amino acids in a Cross-metathesis coupling. The reversibility of the reaction, the modified amino acids, and the dynamic biomimetic aspects were all of interest in this study On new types of cyclic peptidomimetics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 23, 2005
- Accession Number
- ADA431183
Entities
People
- Eric Enholm
- Tammy K. Low
Organizations
- University of Florida