Discovery of Novel Mammary Developmental and Cancer Genes Using ENU Mutagenesis
Abstract
Discovery of novel mammary developmental and cancer genes using ENU mutagenesis This project seeks to discover new genes involved in mammary gland carcinogenesis, by screening for reduced latency to palpable mammary tumors in response to the myc oncogene, that is produced by the loss of a second gene knocked out by random ENU mutagenesis. This project draws upon the large scale recessive ENU mutagenesis project at the John Curtin School Australian National University. We have successfully imported, rederived and cleared from Quarantine the bi-transgeneic inducible myc model of mammary carcinogenesis devised by Prof. Lewis Chodosh. We have established and expanded the colony and we have begun production of animals to be mated with ENU mutagenised animals. We are currently approximately 2 months behind our statement of work, due mainly to a delay experienced in the importation process. On the positive side the construction of a very large new mouse facility at the Australian National University is ahead of time and is due for commissioning in April next year, which should decrease the time required for pedigree screening and-expansion in 2004 and 2005.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2004
- Accession Number
- ADA431370
Entities
People
- Christopher J. Ormandy
Organizations
- Garvan Institute of Medical Research