Interrogating Androgen Receptor Mediated Gene Expression and Tumor Progression by Molecular Imaging

Abstract

This annual report contains data demonstrating the effectiveness of a new adenovirus based optical imaging vector. The vector was injected into human tumors implanted into SCID mice. Animals were injected with D-luciferin and imaged in a Xenogen IVIS device. The vector was able to detect enhanced MAPK levels stimulated by Epidermal Growth Factor in prostate cancer tumors of xenograft animals. The vector was also able to detect inhibition by the small molecule EGF receptor inhibitor Iressa. The data suggest the possibility that gene expression based imaging may be able to detect augmented MAPK levels predictive of disease progression as well as the efficacy of cancer therapeutics.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2004
Accession Number
ADA431376

Entities

People

  • Michael F. Carey

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Cells
  • Charge Coupled Devices
  • Culture Techniques
  • Diseases And Disorders
  • Gene Expression
  • Inhibition
  • Inhibitors
  • Molecules
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Small Molecules
  • Therapy
  • Xenografts

Readers

  • Breast cancer cell signaling and growth regulation.
  • Immunology
  • Oncology and Biomarker-Based Cancer Detection.