Functional Disruption of the Netrin-1 Guidance Cue Leads to Disruption in Mammary Gland Development and Increased Tumor Incidence
Abstract
My laboratory discovered a mammary receptor for netrin-l called neogenin, and I proposed to examine the stromal phenotype associated with the loss of function of neogenin using transplant analysis. Analysis of homozygous null mammary tissue versus wildtype revealed no changes in tissue morphology due to the loss of neogenin function during adolescent development. The investigation is still underway as additional stages of mammary gland development are analyzed. These experiments will extend our study of netrin-l and its receptor neogenin during mammary gland development, and potentially yield insights into the role netrin-l plays in mediating stromal/epithelial interactions during normal breast growth and malignant breast disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA431578
Entities
People
- Lindsay Hinck
Organizations
- University of California, Santa Cruz