Molecular Characterization of Resistance
Abstract
This is a final report of an IDEA Award to study the molecular mechanisms driving acquired antiestrogen resistance. We have identified several genes associated with resistance to ICI 182,780 (Fulvestrant. Faslodex). Additional studies with NFkB reversal with parthenolide have now been completed and submitted for publication (accepted pending minor revisions). Further functional studies on the role of IRF-1 using a dominant negative construct have been published (Bouker et al Cancer Res 64:4030, 2004) and we have collaborated on an additional study that has identified a new estrogen receptor variant in our hormone resistant cells (Han et al. J Mol Endocrinol 32: 935, 2004). This award (entire period) has resulted in the publication of 9 full papers, two reviews, 7 abstracts, and we have two additional papers to be submitted within the next month. Thus, we have made substantial progress in defining initial components of a broader antiestrogen signaling network that is directly associated with acquired antiestrogen resistance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA431580
Entities
People
- Robert Clarke
Organizations
- Georgetown University