Applications of Nanoparticles/Nanowires and Carbon Nanotubes for Breast Cancer Research
Abstract
The purpose of this research is to develop a new technique of using carbon nanotubes for breast cancer detection, diagnosis and killing of cancer cells. This can be achieved by fabrication of single wall carbon nanotubes, separation of carbon nanotubes, fimcfl'onalfzation of antibodies on carbon nanotubes and studying the interaction of carbon nanotubes on cancer cells. This research investigated the effects of ftmctionalization of carbon nanotubes (CNTs) with a primary monoclonal mouse immunoglobin (IgG) specific to the cell-surface receptors of breast cancer cells. Co-localization for CNTs in combination with the primary antibody conjugated to the secondary was determined to be 90%. Specific functionalization of antibodies on carbon nanotubes surfaces were achieved by using an amine terminated PEG molecule that specifically attaches to the primary antibody specific to the cell surface receptors of the breast cancer cell, Preliminary studies on the electrical measurements of the primary mouse IgG incubated with cNTs show a decrease in conductance compared to that of bare CNT field effect transistors (cNTFETs). This observed change in conductance is being currently used as the basis to develop a biosensor for single cell cancer detection systems.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA431597
Entities
People
- Balaji Panchapakesan
Organizations
- University of Delaware