NSAIDS and the Osteogenic Response to Mechanical Stress in Premenopausal Women

Abstract

The primary aim of this randomized, double-blinded, placebo-controlled trial is to determine the effects of NSAID (ibuprofen) use on the osteogenic response to 9 months of exercise training in 102 women. The scientific rationale for this study centers on the knowledge that the osteogenic response to mechanical stress is a prostaglandin (PG)- dependent process and that NSAIDs inhibit PG synthesis. There is evidence that regular NSAID use inhibits the normal bone formation response to mechanical loading, increases risk of fracture, and impairs bone healing. The approved statement of work for this project includes 4 years of recruiting, testing, and training subjects as well as completing sample assays, data analysis, and manuscripts.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2004
Accession Number
ADA431601

Entities

People

  • Wendy M. Kohrt

Organizations

  • University of Colorado Health

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • African Americans
  • Biomedical Research
  • Biomolecules
  • Body Composition
  • Bone Diseases
  • Bone Fractures
  • Chemical Compounds
  • Data Analysis
  • Estrogens
  • Hormones
  • Menstrual Cycle
  • Osteogenesis
  • Prostaglandin
  • Sex Hormones
  • Spine
  • Training

Fields of Study

  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Clinical Trial Research.
  • Trauma Surgery or Emergency Medicine.