Optimization of Breast Cancer Treatment by Dynamic Intensity Modulated Electron Radiotherapy

Abstract

Since electron arc dose calculations using Monte Carlo are quite time-consuming, we have investigated "gross optimization" techniques that will allow determination of a set of starting parameters that can converge to final values within a few iterations. This will allow us to determine the final optimized leaf settings for each arc segment within a reasonable time. Included in this "gross optimization" will be use of precalculated fluence maps reflective of the treatment head geometry, so that the initial parameter set can be determined using Monte Carlo calculations only within the individual patient anatomy. These techniques will make determination of the final leaf settings very straightforward. Additionally, beam data sets have been verified for the clinical range of field sizes and energies. Lastly, we are working with Varian Medical Systems to determine a transition path from our one-of-a-kind electron arc configuration into a supportable system that can be readily available to the general radiotherapy community.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2004
Accession Number
ADA431743

Entities

People

  • Dennis D. Leavitt

Organizations

  • University of Utah

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Breast Cancer
  • Data Sets
  • Electron Beams
  • Electron Energy
  • Electron Scattering
  • Electrons
  • Geometry
  • Intensity
  • Linear Accelerators
  • Neoplasms
  • Optimization
  • Radiotherapy
  • Scattering
  • Shape
  • Therapy
  • Three Dimensional
  • Two Dimensional

Fields of Study

  • Medicine
  • Physics

Readers

  • Computational Modeling and Simulation
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Microelectronics