Estrogen Metabolism Genes and Breast Cancer: An Innovative Approach
Abstract
We proposed to examine associations of CYP17, CYPl9, CYP1BI, and COMT polymorphisms and breast cancer risk using an innovative family-based design among families participating in the Metropolitan New York Breast Cancer Registry (MNYBCR), one of the six sites for National Cancer Institute (NCT)-initiated Cooperative Family Registry for Breast Cancer Studies (CFRBCS) project. To date, we have accomplished all tasks in the approved Statement of Work as planned. We found the CYPl9 allele with 11 TTTA repeats to be associated with breast cancer risk in these families. We also found that maternal (but not paternal) carrier status of CYPl9 alleles with 11 repeats tended to be associated with breast cancer risk in daughters (independent of the daughters' own genotype), suggesting a possible in-utero effect of CYPl9 We found no association of a woman's breast cancer risk with either her own or her mother's genotype of CYP17, CYP1BI, or COMT gene. To date, all the work has been completed and we have published two manuscripts to report the findings.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA431792
Entities
People
- Habibul Ahsan
Organizations
- Columbia University