Inherited Susceptibility to Breast Cancer in Healthy Women: Mutation in Breast Cancer Genes, Immune Surveillance, and Psychological Distress

Abstract

The purpose of the research supported by this IDEA grant award, is to test the possibility that variability in the strength of immune surveillance mechanisms against cancer (operationally defined by assessment of natural killer cell activity) may be a factor in determining the penetrance of mutations in breast cancer susceptibility genes. Two possible explanations for variability in NK cell activity are being investigated: 1) stress-induced immune suppression, and 2) inherited deficits in immune surveillance. This year, we have collected data on 40 women for a total of 224 participants to date out of a planned 240. We have therefore requested a final one-year no-cost extension of the award to allow completion of data collection, analysis, and preparation of presentations and- publications in accordance with the program of work.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2004
Accession Number
ADA431795

Entities

People

  • Dana H Bovbjerg

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adaptive Immunity
  • Biomedical Research
  • Blood
  • Breast Cancer
  • Cells
  • Genetic Testing
  • Immune System
  • Lymphocytes
  • Medical Genetics
  • Medical Personnel
  • Mutations
  • Neoplasms
  • New York
  • Risk Factors
  • Social Psychology
  • Surveillance

Readers

  • Molecular and genetic basis of cancer.
  • Oncology
  • Technical Research and Report Writing.