Influence of Nutrition and Physical Forces on Bone Structure/Function Properties
Abstract
The purpose of this research program is to contribute towards two major objectives in support of advancing our ability to prevent or treat bone failure or fragility: 1. Developing and characterizing methods of evaluating bone properties in animal models that goes beyond measures of bone density and global mechanical properties. 2. Evaluating the influence of physical forces and nutritional status on bone biomechanical integrity. Specifically, it was the purpose of this study to apply a hierarchical approach to quantifying the properties of murine bone to the level of the extracellular matrix. Furthermore, the study was designed to test hypotheses concerning the interplay between vitamin D and calcium nutritional support and physical forces. Progress during the third year has followed the proposed statement of work. 394 animals have been completed and nearly all the vertebra, femurs and tibias have been evaluated geometrically, morphologically and mechanically. Genetic strain has a significant influence on properties, but exercise has had little effect. Nutrition is also important. From a histologic perspective, the tissue constituency is unaffected, suggesting only geometric variations, not inherent material changes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2004
- Accession Number
- ADA431879
Entities
People
- Steven A. Goldstein
Organizations
- University of Michigan