Epidermal Growth Factor (EGF) Receptor Intron 1 CA Repeat Polymorphisms in African-American and Causcsian Males: Influence on Prostate Cancer Risk or Disease Progression and Interaction with Androgen Receptor CAG Repeat Polymorphisms
Abstract
We are investigating the effect of a polymorphic epidermal growth factor receptor (EGFR) gene intron 1 CA repeat on prostate cancer (CaP) development, alone or in combination with a known androgen receptor gene CAG repeat polymorphism. We will characterize these repeats in DNA from African-American and Caucasian men with CaP. The data will be analyzed for any correlation using both parameters with clinical outcome (age of onset, rapid progression, or metastasis). The Human Subjects Protocol was approved by the US Army -Medical Research and Materiel Command Human Subjects Research Review Board (USAMRMC HSRRB) on 24 -November of 2003. However, the resignation of the individual who was to recruit subjects at the Cooper Hospital/ University Medical Center this year and the failure of my clinical collaborator to train a new coordinator in a timely manner has resulted in additional delays in initiating subject recruitment. Fortunately new clinical collaborators affiliated with a major research institution have agreed to participate in the study. Since no subjects have entered the study, there is no data to report. A new Human Subjects Protocol has been submitted to the IRB and DOD HSRRB to indicate the new clinical personnel, and' we anticipate initiating subject recruitment shortly.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA431896
Entities
People
- David K. Moscatello
Organizations
- Coriell Institute for Medical Research