Discovery of Novel Metastasis Genes in Breast Cancer

Abstract

Under this proposal we plan to identify genes that drive the homing of invasive primary breast cancer to its metastatic sites. For the discovery of such genes, in vivo phage display of breast cancer cDNA libraries is used. Validation is achieved by expression monitoring in histological sections as well as by functional assays. In the current series of studies we validated the breast cancer library. We obtained the first results from the in vivo selection. We report those data here

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2004
Accession Number
ADA432037

Entities

People

  • Anton Wellstein

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Anhydrides
  • Biomedical Research
  • Blood
  • Bone Marrow
  • Breast Cancer
  • Cancer
  • Carrier Proteins
  • Cells
  • Endothelial Cells
  • Gene Expression
  • Genetic Structures
  • Histological Techniques
  • Mammary Glands
  • Metastasis
  • Neoplasms
  • Pancreas
  • Polymerase Chain Reaction

Fields of Study

  • Biology

Readers

  • Aerospace Test and Evaluation
  • Molecular Genetics
  • Oncology