Immunologic Response to Cryoablation of Breast Cancer
Abstract
The objective of this project is to characterize the anti-tumor immunologic response to cryosurgery a new minimally invasive approach to the ablation of breast cancer. The work consists of both murine and human studies, expanding upon reports that cryosurgery of primary tumors has been reported to be capable of developing specific anti-tumor immunological responses that can prevent the growth of micrometastasis. Because of conflicts with other grant support the grant was relinquished effective August 31, 2003. While the project is ongoing several interesting findings were discovered. Murine studies, utilizing the MT-901 mammary adenocarcinoma cell line in BALB/c mice, demonstrated a Th1 cytokine response to cryoablation as compared to surgical excision. Mice treated with cryoablation had long-term tumor specific memory as demonstrated by tumor re-challenge. Immunologic studies demonstrated an early but brief antibody response, a regional T-cell response and a systemic NK cell response, although no long- lasting systemic T-cell response could be identified. A manuscript is presently in preparation. Human immunologic studies have been initiated, but the results are too early for interpretation at this time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA432155
Entities
People
- Michael S. Sabel
Organizations
- University of Michigan