PET Radiotracers for Imaging the Proliferation Status of Breast Tumors

Abstract

The goal of this research project is to develop radiotracers for imaging the proliferative status of breast tumors using the noninvasive imaging technique, Positron Emission Tomography (PET). The strategy taken involves developing radiotracers having a high affinity and selectivity for the sigma (sub 2) receptor, which has been shown to be a useful receptor-based biomarker of proliferation in breast tumor cells growing both in vitro and in vivo. During the second year of the three-year IDEA project, we identified a new class of ligands displaying an outstanding affinity and selectivity for sigma (sub 2) versus sigma (sub 1) receptors. Preliminary in vivo biodistribution and microPET imaging studies with Br-76, C-11 and I-125-labeled analogs indicate that these agents may be useful for use in the diagnosis and determination of the proliferative status of breast tumors in breast cancer patients.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2004
Accession Number
ADA432165

Entities

People

  • Robert H. Mach

Organizations

  • Washington University in St. Louis

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Brain
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chlorides
  • Data Analysis
  • Department Of Defense
  • Drug Abuse
  • Glass Fibers
  • Imaging Techniques
  • Neoplasms
  • Organic Chemistry
  • Positron Emission Tomography
  • Rodents

Fields of Study

  • Medicine
  • Physics

Readers

  • Materials Science.
  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.