The Establishment of an Inflammatory Breast Cancer Registry and Biospecimen Repository
Abstract
The Inflammatory Breast Cancer (IBC) Registry enrolled its first patient Sept. 10, 2002. As of July 31, 2004, 163 patients have contacted the Registry and 135 have completed their interviews. Tissue blocks have been obtained from 110 patients and frozen surgical specimens have been collected from 10. Five laboratories were sent biospecimens and results continue to be obtained. Data on the first 50 patients were presented at the San Antonio Breast Cancer Conference in December 2003 and initial evaluation of the questionnaire data will be presented at the San Antonio Breast Cancer Conference in December 2004. The clinical data include the observation that approximately one third of IBC patients are initially diagnosed as having mastitis and are treated with up to five months of antibiotics before the diagnosis of cancer is made. Less than 25% of patients have a discrete mass identified on initial mammography. Laboratory data thus far (45 patients) indicate that the tumors from all patients express significant amounts of BP-1, a homeobox gene associated with breast cancer aggressiveness. In addition, tumors from a higher percentage of IBC patients express gene sequences resembling mouse mammary tumor virus than non-IBC breast cancer patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2004
- Accession Number
- ADA432933
Entities
People
- Paul H. Levine
Organizations
- George Washington University