Development of a Cell-Based Biosensor for Compound Detection
Abstract
The threat of environmental pollution, biological warfare agent dissemination, and new diseases has in recent decades increased research into high throughput cell-based biosensors (Bousse, 1996; Gross et al., 1997; Jung et al., 1998). The creation of this class of biosensors could specifically aid in the detection of hazardous bioagents and other toxins. Understanding the validity and sensitivity of these sensors should also help with determining the mechanisms of drug- and chemical- induced toxicity (Davila et al, 1998). The current systems have been validated using a wide-range of toxins including synthetic pesticides, common heavy metals, and widely studied drugs used in treating cardiac dysfunction. We have tested these various bioagents on two different systems - MEAs and FETs, and have found that they can be used for testing in a high throughput platform for toxicity evaluation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2004
- Accession Number
- ADA432949
Entities
People
- Arun Natarajan
- D. C. Leistritz
- J. J. Hickman
- K. Varghese
- P. Molnar
Organizations
- University of Central Florida