A Study of Transrectal Tumor Oxygen Measurements in Patients Which Clinically Localized Prostate Cancer
Abstract
The primary aim of this clinical study is to determine the relationship between pre-treatment prostate cancer oxygen levels and long-term disease control following treatment with radiotherapy, and the independent prognostic effect of oxygen measurements relative to established prognostic factors. In addition, the study will determine the relationship between pre-treatment tumor oxygen levels and mutations of the p53 tumor suppressor gene, and the impact of this interaction on patient outcome. It is anticipated that the accrual target of 195 patients will be achieved by July 31, 2005. The oxygen measurement technique was revised based on our pilot study to assure that the highest quality data are being collected. The microregional distribution of oxygen in prostate cancer biopsies will be studied using intrinsic markers of oxygenation. The molecular studies' of p53 are proceeding as outlined in the proposal. A preliminary analysis suggested a potentially important influence of prostrate cancer hypoxia on patient outcome following treatment with radiotherapy, in agreement with the underlying hypothesis of the study. However, longer patient follow-up is required to confirm this early result. It is anticipated that all aspects of the proposed work will be completed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2004
- Accession Number
- ADA433026
Entities
People
- Michael F. Milosevic
Organizations
- University Health Network