Tolerance to the Ocular and Cardiovascular Effects of Repeated Low-Level Exposure to Sarin Vapor

Abstract

Inhibition of acetylcholinesterase (AChE) by the nerve agent sarin (GB) results in accumulation of acetylcholine and excessive cholinergic stimulation. Little data exists in the literature regarding the effects of low-level repeated exposure to GB vapor. In the present study male rats were exposed to multiple low-level inhalation exposures to GB vapor. The data from the present study demonstrate that multiple inhalation exposures to GB vapor result in tolerance to the ocular and autonomic effects of GB vapor. While the observed decrease in the potency of GB in rats cannot he attributed to a reduction in the inhibitory effect of GB additional experiments are needed to determine the exact mechanism of the tolerance observed.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2004
Accession Number
ADA433060

Entities

People

  • B. J. Benton
  • D. B. Miller
  • D. C. Burnett
  • E. A. Davis
  • E. K. Kerut
  • E. M. Jakubowski
  • P. A. Dabisch
  • S. D. To
  • S. W. Hulet
  • W. T. Muse

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Acetylcholinesterases
  • Acquisition
  • Autonomic Nervous System
  • Bioengineering
  • Chemical Warfare Agents
  • Frequency
  • Health Services
  • Heart
  • Heart Rate
  • Measurement
  • Nerve Agents
  • Nerves
  • Nervous System
  • Rodents
  • Sympathetic Nervous System
  • Two Dimensional

Readers

  • Cardiovascular Physiology
  • Neurotoxicology
  • Underwater engineering and Marine Technology.