Potential Use of Stem Cell Therapy for Traumatic Brain Injury

Abstract

Traumatic brain injury (TBI) accounts for a significant proportion of combat casualties as well as civilian trauma. Pharmaceutical interventions for brain trauma, in general, met with limited success and are often compounded by serious side effects. Recent research and technology on stem cell transplantation have opened up a novel means for ONS repair. This study aims to investigate the therapeutic potential of neural differentiation of stem cells from umbilical cord blood for neural repair following TBI. The present results have shown an in vitro differentiation of stem cells into neural lineages. These cells expressed neural markers nestin, Map2, GFAP and ONPase as detected by immunohistochemistry. Animals that received neural stem cells showed improved neurological functions when compared with control groups. This study has shown the differential and therapeutic potential of stem cells from umbilical cord blood which may be used as an alternative or a complementary therapy for traumatic brain injury.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2004
Accession Number
ADA433082

Entities

People

  • Lu Jie
  • S. Moochhala

Organizations

  • Defence Science Organisation

Tags

DTIC Thesaurus Topics

  • Blood
  • Brain
  • Brain Injuries
  • Cells
  • Central Nervous System
  • Cerebral Cortex
  • Cerebrovascular Disorders
  • Cultured Cells
  • Fetus
  • Health Services
  • Neuroglia
  • Neurons
  • Neuroplasticity
  • Proteins
  • Side Effects
  • Stem Cells
  • Transplants

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Biotechnology