Healing of Stress Fracture in an Animal Model
Abstract
This project aims to develop effective ways to prevent or treat stress fractures. We have successfully established a reproducible stress fracture model in the rodent. We have investigated the role of an exercise program in the prevention of stress fractures using the ulna axial compression loading model. Loading was applied on right ulnas using a 2-Hz haversine waveform with a peak force of 17 N for 360 cycles/day, three days per week for five consecutive weeks. After adaptation to mechanical loading was determined by assessing both the material and structural properties of each ulna, ulnas (loaded vs. nonloaded) were loaded at a constant peak load of 25 N using a 5 Hz haversine waveform until fatigue failure. Loading improved both the material and structural properties of the ulna, especially minimum second moment of area increasing about 2-fold. Loaded ulnas failed in fatigue after 1.3 million cycles, compared to the 16,850 cycles required for non-loaded ulnas, suggesting that the mechanical loading program increased the fatigue resistance by 80-fold. In addition, animal experimental parts regarding the individual and combined roles of anti-inflammatory agent (cyclooxygenase-2 inhibitor) and low-intensity pulsed ultrasound in the treatment of stress fractures were done.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA433113
Entities
People
- Jiliang Li