Effect of Recombinant FVIIA in Hypothermic, Coagulopathic Pigs with Liver Injuries
Abstract
A study was conducted to evaluate effects of the drug, recombinant activated Factor VII (rFVIIa) on survival, survival time, blood loss, and disseminated intravascular coagulation (DIC) in hypothermic, coagulopathic swine subsequent to severe liver injury and associated hemorrhage. Swine were anesthetized, and catheters were placed in the carotid artery, in the jugular, and in the femoral artery. After midline laparotomy, splenectomy and stabilization of blood pressure, pH, and body temperature, approximately 60% of the blood was removed and replaced with 6% Hetastarch (Hespan) maintained at 33 degrees C. Hemodilution was followed by adjustment of body temperature to 32.5 +/- .5 degrees C. Subsequently, a severe liver injury was produced using a specially designed clamp with associated cross-blades. After 30 sec, either vehicle control or treatments were administered intravenously during a 30 second period. Resuscitation with 33 degrees C Lactated Ringers was initiated at 4.5 min post injury. In this pig model, these data indicate all inability of these doses of rFVIIa to reduce blood loss, increase percent survival or increase survival time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2005
- Accession Number
- ADA433431
Entities
People
- Allen Burke
- Angel V. Delgado
- Douglas Cortez
- Harold G. Klemcke
- John B Holcomb
- John Uscilowicz
- Joseph Macaitis
- Kathy L. Ryan
- Michael Scherer
- Rodolpho Deguzman
Organizations
- United States Army Institute of Surgical Research