Development of Biomimetic Surfaces by Vesicle Fusion
Abstract
In this study fusion of lipid-peptide amphiphile vesicles is employed to form biomimetic coating materials that can modify cellular adhesion and growth on solid substrates. Ellipsometry has been used to monitor vesicle fusion at different concentrations on hydrophilic surfaces and to identify adsorption as its limiting step. Incorporation of small amounts of RGD containing peptide amphiphiles in cell adhesion resistant PC lipid membranes is shown to promote adhesion and growth only when a sufficiently long spacer is used to control the distance of the peptide ligand from the surface.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2004
- Accession Number
- ADA433455
Entities
People
- Alejandro Parra
- Dimitrios Stroumpoulis
- Jill Gliem
- Matthew Tirrell
Organizations
- University of California, Santa Barbara