Stochastic Fluctuations in Gene Regulation

Abstract

This project developed improved theoretical and simulation techniques that take account of stochastic fluctuations in gene expression and lead to reliable predictions of complex cell behaviors. These techniques and associated models were tested and refined through experimental studies using engineered gene circuits. Through this integrated approach, a hierarchical simulation approach to describe, predict and control complex gene networks in living cells are developed and incorporated into BioSPICE.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2005
Accession Number
ADA433773

Entities

People

  • A. Van Oudenaarden
  • J. Collins
  • T. Elston

Organizations

  • Boston University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Air Force
  • Air Force Research Laboratories
  • Classification
  • Gene Expression
  • Information Operations
  • Military Research
  • New York
  • North Carolina
  • Regulations
  • Security
  • Simulations
  • Standards
  • Universities

Fields of Study

  • Biology

Readers

  • Computational Modeling and Simulation
  • Molecular and genetic basis of cancer.
  • Research Science/Academic Research