Role of PSMA in Aberrant Cell Cycle Progression in Prostate Cancer
Abstract
Prostate specific membrane antigen (PSMA) is a well-studied, highly restricted prostate epithelial cell membrane antigen. In contrast to other highly restricted prostate-related antigens such as prostate specific antigen (PSA) and prostatic acid phosphatase (PAP), which are secretory proteins, PSMA is an integral membrane protein. In addition to its prostate specificity, PSMA is expressed by a very high proportion of prostate cancers (Pca), expression is further increased in higher grade cancers, in metastatic disease, and in hormone-refractory PCa. Among reasons for significant interest in PSMA is that it is ideal for in vivo prostate-specific targeting strategies. Although PSMA is primarily localized to the plasma membrane immunofluorescence analysis also revealed its localization to a membrane compartment around the centrosome. Consistent with its localization around the centrosomes PSMA expressing cells rapidly exited mitosis. We have now determined that the association 6% the cytoplasmid tail of PSMA with key regulators of cell cycle progression is involved the aberrant mitotic exit of PSMA expressing cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2004
- Accession Number
- ADA433876
Entities
People
- Ayyappan K. Rajasekaran
Organizations
- University of California, Los Angeles