Antioxidant Prophylaxis in the Prevention of Prostatic Epithelial Neoplasia
Abstract
Although prostate cancer is considered to be a disease of older men, a significant number of young men exhibit the earliest signs of prostate cancer. This suggests that the disease is initiated early and remains latent until some factors trigger it to become malignant. The long latency of prostate cancer progression provides an opportunity for interventions to prevent the disease from becoming cancerous. Since treatment options for prostate cancer are very limited for the initial stages of the disease and unavailable for metastatic disease, it is imperative that other means to control the disease be tested to reduce the number of prostate cancer deaths in the United States. Oxidants produced as byproducts of cellular metabolism have been implicated in the genesis of prostate cancer. Oxidative stress is caused by an imbalance of cellular endogenous oxidant and antioxidant levels. Laboratory studies indicate that oxidative stress markers increase and antioxidant enzyme levels decrease during prostate cancer progression. Oxidative stress generated by dietary fat and androgens has been implicated in prostate cancer. Epidemiological studies with a variety of antioxidants have been found to be effective in lowering prostate cancer risk. However, these studies are flawed in that they do not add to our understanding of the nature and amounts of antioxidants that are beneficial. The authors hypothesize that a combination of antioxidants can prevent or delay the development of prostatic intraepithelial neoplasia (PIN) in a T/E(sub 2) model of PCA by modulating the level of oxidative stress markers and endogenous antioxidant levels. The focus of Year 1 was to determine the ability of antioxidants to prevent or delay the development of PIN and relate it to changes in T/E(sub 2) in serum and AR. This phase involved breeding Noble rats, starting antioxidant supplementation, initiating PIN formation with hormones, and stopping the feeding after 16 and 32 weeks.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2005
- Accession Number
- ADA433901
Entities
People
- A. P. Kumar
- Lori Gardner
- Nicole Arevalo
- Rita Ghosh