Temporal and Spatial Dynamics of DNA Topoisomerase I in Prostate Cancer

Abstract

The purpose of this proposal was to investigate the response of prostate cancer to a series of camptothecin analogs, which are drugs that target DNA topoisomerase I. Toward task 1 of our proposal, we used immunofluorescence staining. However, this did not provide satisfactory results due to non-specificity of the rabbit serum used. We focused predominantly on tasks related to the data obtained from the completed task 3. We developed a very potent camptothecin analog that shows good activity in prostate cancer.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADA433934

Entities

People

  • Randy M. Wadkins

Organizations

  • University of Mississippi

Tags

DTIC Thesaurus Topics

  • Alkaloids
  • Apoptosis
  • Biological Staining And Labeling
  • Biomedical Research
  • Cell Line
  • Cells
  • Clinical Trials
  • Drug Resistance
  • Dynamics
  • Electronic Mail
  • Hydrogen Bonds
  • Hydrophilic Properties
  • Immunostaining
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Universities

Fields of Study

  • Biology

Readers

  • Oncology and Biomarker-Based Cancer Detection.
  • Radar Systems Engineering.
  • Systems Analysis and Design