Tc-99m Labeled and VIP Receptor Targeted Liposomes for Effective Imaging of Breast Cancer

Abstract

The primary goal of this past year's work was to determine the in vivo behavior of the targeted sterically stabilized liposomes incorporating Tc99m which we developed in the previous year, in rats bearing carcinogen-induced breast cancer. The blood profile of VIP-SSL was determined in comparison to SSL to evaluate its circulation behavior and its longevity in the circulation. The targeted system was then evaluated for its passive and active targeting ability in vivo by determining the tumor and tissue distribution of the Tc99m-loaded SSL with and without surface VIP in rats with breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2004
Accession Number
ADA433960

Entities

People

  • Hayat Önyüksel

Organizations

  • University of Chicago

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Arteries
  • Body Weight
  • Breast Cancer
  • Cancer
  • Chemotherapy
  • Ethylene Glycol
  • Ethylenes
  • Filtration
  • Gamma Counters
  • Glycols
  • Health Services
  • Light Scattering
  • Materials
  • Membrane Lipids
  • Molecules
  • Radioactivity

Readers

  • Molecular and Cellular Biochemistry
  • Molecular and genetic basis of cancer.