Blood-Brain Barrier Transport of Uranium

Abstract

The purpose of this study is to assess the substrate specificity of uranium (U) transport into the central nervous system. the Principal Investigator (PI) plans to examine the in vitro transport of U across the blood-brain barrier (BBB) in endothelial cells in vitro and to study the in vivo transport of U across the BBB in a rat model. During the third year of the study the PI cultured rat brain endothelial 4 cells (RBE4) for in vitro assessment of U transport and end points of neurotoxicity. The following sections summarize the results that have been obtained during year 3 of the proposal.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2004
Accession Number
ADA433990

Entities

People

  • Michael Aschner

Organizations

  • Wake Forest University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Blood
  • Blood-Brain Barrier
  • Body Fluids
  • Body Weight
  • Brain
  • Cells
  • Central Nervous System
  • Endothelial Cells
  • Hippocampus
  • Nervous System
  • Proteins
  • Substrate Specificity
  • Transport Ships

Readers

  • Cardiovascular Physiology
  • Neuroscience
  • Virology (or Medical Virology).