Retinoid and Histone Deacetylase Inhibitors in the Treatment of Prostate Cancer

Abstract

Retinoids, derivatives of vitamin A (Retinol), are required for the appropriate differentiation of normal human prostate epithelial cells. Human prostate cancer cell contain much lower levels of vitamin A and its metabolites than normal cells. We hypothesize that aberrant metabolism of vitamin A and dysregulation of gene expression in prostate tumor cells are related to the abnormal growth properties of the tumor cells. A rationale for using retinoids in prostate cancer chemotherapy is further supported by the effectiveness of ATRA (all-trans Retinoic Acid), a vitamin A metabolite, in the treatment of acute promyelocytic leukemia (APL).

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2004
Accession Number
ADA434048

Entities

People

  • Lorraine J. Gudas

Organizations

  • Cornell University

Tags

DTIC Thesaurus Topics

  • Acids
  • Anticonvulsants
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chemotherapy
  • Enzyme Inhibitors
  • Epithelial Cells
  • Gene Expression
  • Medical Personnel
  • Neoplasms
  • Retinoic Acids
  • Statistical Analysis
  • Therapy
  • Tissues

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Prostate Cancer Biology.