Enhanced T Cell Attack of Brain Micro-Metastases
Abstract
Brain-metastasizing breast cancer is a major clinical problem. Cell-mediated immunotherapy is well-suited to attack it, but an appropriate small animal model was needed. In this final period (no-cost extension), we have worked to simplify and validate the model we have been developing. We present a novel model for visualizable, sporadic blood-borne micro-metastases of mammary carcinoma in the rat brain. We present evidence that tumor can enter the brain by vessels at all three relevant sites: vessels in the brain proper, in the meninges, and in the choroid plexus. in parallel, we describe how, during the course of this project, our own work and others' has changed our thinking about the best form of Immunotherapy for blood-borne micro-metastases in the brain. We report that the work in the project has enabled us to obtain one new NIH grant, and Is vital to a second one that is now being submitted. In a broader context, the PI's efforts to encourage fresh thinking about brain tumor trails ("Strengthening the Bridge from Bench to Bedside") are described.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA434049
Entities
People
- Lois Lampson
Organizations
- Brigham and Women's Hospital