Phytoestrogen Effects on Cytoskeletal Morphology and Motility in Breast Cancer Progression
Abstract
The purpose of the proposed study is to determine rapid effects of resveratrol, genistein, and daidzein on Rho GTPases and downstream effectors involved in breast cancer cell motility. The scope of the study is to determine signaling pathways affected by the phytoestrogens regarding cell motility and to use confocal microscopy to track in vivo the metastatic potential of cells treated with phytoestrogens in mice. To date, there are no major findings associated with this investigation because at the same time the PI was awarded this DoD fellowship, the PI was also awarded a NIH fellowship and chose to take the NIH award for research support. Dr. Katherine Moore advised the PI to keep the DoD award and transfer the support to a new graduate student in fall 2005. The PI has not initiated the proposed project nor has the PI used any of the funding. In September 2005, a new fellow will be named and the funding will be transferred. No key accomplishments or reportable outcomes have been completed as the project was never initiated and has been put on hold until a new recipient is named.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2005
- Accession Number
- ADA434058
Entities
People
- Nicolas G. Azios
- Surangani Dharawardhane
Organizations
- University of Texas at Austin