Synthetic Lethality in Breast Cancer Cells: Genes Required for Tumor Survival
Abstract
The conversion of a normal cell into a cancer cell proceeds through a series of genetic and epigenetic alterations. We have proposed to use well-established genetic methodologies to identify novel anti-cancer targets via their specific, genetic interactions with common cancer mutations. In short, we will identify genetic alterations that are neutral in normal cells, but that are lethal when combined with cancer mutations. This "synthetic lethality" approach may identify potential therapeutic targets that are highly specific to the cancer cell.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA434066
Entities
People
- Gregory Hannon
Organizations
- Cold Spring Harbor Laboratory