Dietary Fat, Fat Metabolizing Genes, and Prostate Cancer Risk in African-Americans and Whites
Abstract
Dietary fat has been implicated as a potential promotional factor leading to progression of small latent, non-metastatic prostate tumors to invasive, metastatic lesions. One possible mechanism is conversion of the n-6 polyunsaturated fatty acids to inflammatory compounds produced by the lipoxygenase (LOX) family of enzymes. We are examining whether genetic variants in the n-6 fatty acid LOX pathways are associated with the risk of prostate cancer in a population-based case control study of advanced prostate cancer among African-Americans and whites in Los Angels County. In the first year of the study, we finished genotyping three LOX gene polymorphisms, including 12-LOX G1n261Arg, Ser322Asn, and the 5_LOX promoter Sp1 motif polymorphism. In the second year, further genotyping will be performed and the results will be linked to case control status and questionnaire data for association analyses. We will investigate whether genetic variation in specific LOX pathways, in combination with diet, contributes to prostate cancer risk. Our findings could provide a scientific foundation upon which to design dietary intervention trails and may allow us to design strategies for reducing the disparity in prostate cancer burden between African-Americans and other ethnic groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2004
- Accession Number
- ADA434074
Entities
People
- Sue A. Ingles
Organizations
- University of Southern California