The Role of CXCR4 and Arrestins in Breast Cancer Signaling and Apoptosis
Abstract
G protein--coupled receptors (GPCR) are a family of receptors that are involved in all physiologic and many pathologic processes. Recently, they have been described as playing a critical role in breast cancer metastasis. As all GPCRs interact with arresting, we have sought to better understand the role of arrestin interaction with GPCRs particularly in the process of apoptosis. Previously published data has described the initiation of apoptosis when GPCRs are stimulated in the absence of arrestins. It is therefore our goal to better understand this process and therefore better understand potential roles for GPCRs and arrestins in breast cancer development. From this work, we hypothesize that arrestin can be used as a novel chemotherapeutic target. If arrestins are inhibited, stimulation of GPCRs found on metastatic breast cancer cells may undergo apoptosis therefore providing a new treatment to eradicate breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2005
- Accession Number
- ADA434113
Entities
People
- Brant M Wagener
Organizations
- University of New Mexico