Biomarkers of Selenium Chemoprevention of Prostate Cancer

Abstract

A major goal of this project is to identify suitable biomarkers of selenium chemoprevention in human prostate cell models. These selenium-responsive biomarkers should be: (i) associated with the molecular mechanism of selenium chemoprevention, (ii) changed in a manner that is consistent with cancer risk reduction, and (iii) easily quantifiable in biopsied samples. We used the cDNA microarray technology to identify these biomarkers because it enables us to simultaneously monitor the expression pattern of a wide spectrum of genes in a single experiment.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADA434139

Entities

People

  • Yan Dong

Organizations

  • Health Research, Incorporated

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Biological Factors
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Data Mining
  • Dna Microarrays
  • Gene Expression
  • Genetics
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Proteomics

Fields of Study

  • Biology

Readers

  • Oncology and Biomarker-Based Cancer Detection.
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology